UPDATE: All southbound lanes have reopened, the Colorado Department of Transportation said on its website.

Two were hospitalized after a four-vehicle crash on Interstate 25 in south Colorado Springs early Wednesday, according to Colorado State Patrol.

The crash happened between South Academy Boulevard and Mesa Ridge Parkway around 5:50 a.m. and shut down all southbound lanes for about an hour, State Patrol said. As of 7:30 a.m., one of the southbound lanes has reopened.

Motorcyclist dies after collision with vehicle at North Union Boulevard on Tuesday

Two drivers were taken to the hospital for minor to moderate injuries, a State Patrol spokesperson said. One of the vehicles reportedly struck a guardrail. Investigators are still determining the cause of the crash.

Click or tap here for traffic updates around Colorado Springs.

Click or tap here for updates and alerts from CDOT.

This article will be updated as more information becomes available.

Colorado Springs police: Business suffers 'significant' damage after car crashes into storefront